Publications

Review Articles

Original Research articles

coming soon
Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine.

ASC Nano, March 2016

Fais S, O’Driscoll L, Borras FE, Buzas E, Camussi G, Cappello F, Carvalho J, Cordeiro da Silva A, Del Portillo H, El Andaloussi S, Ficko Trček T, Furlan R, Hendrix A, Gursel I, Kralj-Iglic V, Kaeffer B, Kosanovic M, Lekka ME, Lipps G, Logozzi M, Marcilla A, Sammar M, Llorente A, Nazarenko I, Oliveira C, Pocsfalvi G, Rajendran L, Raposo G, Rohde E, Siljander P, van Niel G, Vasconcelos MH, Yáñez-Mó M, Yliperttula ML, Zarovni N, Zavec AB, Giebel B

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Beyond the exome: the role of non-coding somatic mutations in cancer.

Annals of Oncology, February 2016

Piraino SW, Furney SJ.

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Diagnostic and Therapeutic Implications of Histone Epigenetic Modulators in Breast Cancer.

Expert Review of Molecular Diagnostics, May 2016

Walsh L, Gallagher WM, O’Connor DP, Ní Chonghaile T

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TMetabolic syndrome – a closer look at the growing epidemic and its consequences.

Obesity Reviews, January 2015

O’Neill S, O’Driscoll L.

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Neuromedin U: a multifunctional neuropeptide with pleiotropic roles.
Clinical Chemistry, March 2015

Martinez VG, O’Driscoll L.

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Epidemiologic design and analysis for proteomic studies: a primer on -omic technologies.

American Journal of Epidemiology, May 2015

Mischak H, Critselis E, Hanash S, Gallagher WM, Vlahou A, Ioannidis JP.

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Validation of New Cancer Biomarkers: A Position Statement from the European Group on Tumor Markers.

Clinical Chemistry, June 2015


Duffy MJ, Sturgeon CM, Sölétormos G, Barak V, Molina R, Hayes DF, Diamandis EP, Bossuyt PM.

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Expanding on exosomes and ectosomes in cancer.

New England Journal of Medicine, June 2015


O’Driscoll L.

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Biomarkers in Breast Cancer: Where Are We and Where Are We Going?

Advanced Clinical Chemistry, June 2015


Duffy MJ, Walsh S, McDermott EW, Crown J.

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IGF-1 Receptor and Adhesion Signaling: An Important Axis in Determining Cancer Cell Phenotype and Therapy Resistance

Frontiers in Endocrinology, July 2015


Cox OT, O’Shea S, Tresse E, Bustamante-Garrido M, Kiran-Deevi R, O’Connor R.

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The Role of Exosomes in Breast Cancer.

Clinical Chemistry, December 2015

Lowry MC, Gallagher WM, O’Driscoll L.

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PRC2 mediated H3K27 methylations in cellular identity and cancer

Current Opinion Cell Biology, December 2015

Conway E, Healy E, Bracken AP.

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uPA and PAI-1 as biomarkers in breast cancer: validated for clinical use in level-of-evidence-1 studies.

Breast Cancer Research, August 2014

Duffy MJ, McGowan PM, Harbeck N, Thomssen C, Schmitt M.

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A novel mechanism of regulation of the anti-metastatic miR-31 by EMSY in breast cancer.

Breast Cancer Research, November 2014

Mulrane L, Gallagher WM, O’Connor DP.

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p53 as a target for the treatment of cancer.

Cancer Treatment Reviews, December 2014

Duffy MJ, Synnott NC, McGowan PM, Crown J, O’Connor D, Gallagher WM.

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Metabolic syndrome – a closer look at the growing epidemic and its consequences.

Obesity Reviews, January 2015

O’Neill S, O’Driscoll L.

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miRNA dysregulation in breast cancer.

Breast Cancer Research, 2015, October 2013

Eccles SA, Aboagye EO, Ali S, Anderson AS, Armes J, Berditchevski F, Blaydes JP, Brennan K, Brown NJ, Bryant HE, Bundred NJ, Burchell JM, Campbell AM, Carroll JS, Clarke RB, Coles CE, Cook GJ, Cox A, Curtin NJ, Dekker LV, Silva Idos S, Duffy SW, Easton DF, Eccles DM, Edwards DR, Edwards J, Evans D, Fenlon DF, Flanagan JM, Foster C, Gallagher WM, Garcia-Closas M, Gee JM, Gescher AJ, Goh V, Groves AM, Harvey AJ, Harvie M, Hennessy BT, Hiscox S, Holen I, Howell SJ, Howell A, Hubbard G, Hulbert-Williams N, Hunter MS, Jasani B, Jones LJ, Key TJ, Kirwan CC, Kong A, Kunkler IH, Langdon SP, Leach MO, Mann DJ, Marshall JF, Martin L, Martin SG, Macdougall JE, Miles DW, Miller WR, Morris JR, Moss SM, Mullan P, Natrajan R, O’Connor JP, O’Connor R, Palmieri C, Pharoah PD, Rakha EA, Reed E, Robinson SP, Sahai E, Saxton JM, Schmid P, Smalley MJ, Speirs V, Stein R, Stingl J, Streuli CH, Tutt AN, Velikova G, Walker RA, Watson CJ, Williams KJ, Young LS, Thompson AM.

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coming soon
Preclinical evaluation of the AR inhibitor enzalutamide in triple-negative breast cancer cells.

Endocrine Related Cancers, April 2016

Caiazza F, Murray A, Madden SF, Synnott NC, Ryan EJ, O’Donovan N, Crown J, Duffy MJ.

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Preclinical evaluation of the AR inhibitor enzalutamide in triple-negative breast cancer cells.

Endocrine Related Cancers, April 2016

Caiazza F, Murray A, Madden SF, Synnott NC, Ryan EJ, O’Donovan N, Crown J, Duffy MJ.

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Lysosome triggered near-infrared fluorescence imaging of cellular trafficking processes in real time.

Nature Communications, March 2016

Grossi M, Morgunova M, Cheung S, Scholz D, Conroy E, Terrile M, Panarella A, Simpson JC, Gallagher WM, O’Shea DF.

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AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy irrespective of expression levels and the subcellular localization of Bcl-xL and Bcl-2 in MCF7 cell.

Biochimica et Biophysica Acta (BBA), April 2016

Antonietti P, Gessler F, Düssmann H, Reimertz C, Mittelbronn M, Prehn JH, Kögel D.

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Adaptation to AI therapy in breast cancer can induce dynamic alterations in ER activity resulting in estrogen independent metastatic tumours.

Clinical Cancer Research, January 2016

Varešlija D, McBryan J, Fagan A, Redmond AM, Hao Y, Sims AH, Turnbull A, Dixon JM, Ó Gaora P, Hudson L, Purcell S, Hill AD, Young LS.

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Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer.

Scientific Reports, January 2016

Michaut M, Chin SF, Majewski I, Severson TM, Bismeijer T, de Koning L, Peeters JK, Schouten PC, Rueda OM, Bosma AJ, Tarrant F, Fan Y, He B, Xue Z, Mittempergher L, Kluin RJ, Heijmans J, Snel M, Pereira B, Schlicker A, Provenzano E, Ali HR,Gaber A, O’Hurley G, Lehn S, Muris JJ3, Wesseling J, Kay E, Sammut SJ, Bardwell HA, Barbet AS, Bard F, Lecerf C, O’Connor DP, Vis DJ, Benes CH, McDermott U, Garnett MJ, Simon IM, Jirström K, Dubois T, Linn SC, Gallagher WM, Wessels LF, Caldas C, Bernards R.

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Transcriptomic Profiling of Sequential Tumors from Breast Cancer Patients Provides a Global View of Metastatic Expression Changes Following Endocrine Therapy.

Clinical Cancer Research, December, 2015

McBryan J, Fagan A, McCartan D, Bane FT, Varešlija D, Cocchiglia S, Byrne C, Bolger J, McIlroy M, Hudson L, Tibbitts P, O Gaora PO, Hill AD, Young LS.

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A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence.

Gene and Development, October 2015

Brien GL, Healy E, Jerman E1, Conway E, Fadda E, O’Donovan D, Krivtsov AV, Rice AM, Kearney CJ, Flaus A, McDade SS, Martin SJ, McLysaght A, O’Connell DJ, Armstrong SA, Bracken AP.

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miR-134 in extracellular vesicles reduces triple-negative breast cancer aggression and increases drug sensitivity.

Oncotarget, September 2015

O’Brien K, Lowry MC, Corcoran C, Martinez VG, Daly M, Rani S, Gallagher WM, Radomski MW, MacLeod RA, O’Driscoll L.

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Delineating transcriptional networks of prognostic gene signatures refines treatment recommendations for lymph node-negative breast cancer patients.

FEBS Journal, July 2015


ALanigan F, Brien GL, Fan Y, Madden SF, Jerman E, Maratha A, Aloraifi F, Hokamp K, Dunne EJ, Lohan AJ, Flanagan L, Garbe JC, Stampfer MR, Fridberg M, Jirstrom K, Quinn CM, Loftus B, Gallagher WM, Geraghty J, Bracken AP.

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De-novo post-diagnosis aspirin use and mortality in women with stage I-III breast cancer.

Cancer Epidemiology, Biomarkers and Prevention, June 2015


Barron TI, Murphy LM, Brown C, Bennett K, Visvanathan K, Sharp L.

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MicroRNA-10a is reduced in breast cancer and regulated in part through retinoic acid.

BMC Cancer, May 2015


Khan S, Wall D, Curran C, Newell J, Kerin MJ and Dwyer RM.

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Targeting ADAM-17 with an Inhibitory Monoclonal Antibody Has Anti-tumor Effects in Triple-negative Breast Cancer Cells.

British Journal of Cancer, June 2015


Caiazza F, McGowan P, Mullooly M, Murray A, Synnott N, O’Donovan N, Flanagan L, Tape CJ, Murphy G, Crown J, Duffy MJ.

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Recent Prediagnostic Aspirin Use, Lymph Node Involvement, and 5-Year Mortality in Women with Stage I-III Breast Cancer: A Nationwide Population-Based Cohort Study.

Cancer Research, August 2014

Barron, T. I., Flahavan, E. M., Sharp, L., Bennett, K., and Visvanathan, K.

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Peroxiredoxin-1 protects estrogen receptor alpha from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer

Breast Cancer Research, July 2014

O’Leary, P.C.; Terrile, M., Bajor, M., Gaj, P., Hennessy, B. T., Mills, G. B., Zagozdzon, A., O’Connor, D.P., Brennan, D. J., Connor, K., Li, J.; Gonzalez-Angulo, A. M.; Sun, H. D.; Pu, J. X.; Ponten, F.; Uhlen, M.; Jirstrom, K.; Nowis, D. A.; Crown, J. P.; Zagozdzon, R.; Gallagher, W. M.

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Neuromedin U: a candidate biomarker and therapeutic target to predict and overcome resistance to HER-tyrosine kinase inhibitors.

Neoplasia, July 2014

Rani, S., Corcoran, C., Shiels, L., Germano, S., Breslin, S., Madden, S., McDermott, M. S., Browne, B. C., O’Donovan, N., Crown, J., Gogarty, M.; Byrne, A. T. and O’Driscoll, L.
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Essential function for PDLIM2 in cell polarization in three-dimensional cultures by feedback regulation of the beta1-integrin-RhoA signaling axis.

Neoplasia, June 2014

Deevi, R. K., Cox, O. T., and O’Connor, R.

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PP2A inhibition overcomes acquired resistance to HER2 targeted therapy.

Molecular Cancer, June 2014

McDermott, M. S., Browne, B. C., Conlon, N. T., O’Brien, N. A., Slamon, D. J., Henry, M., Meleady, P., Clynes, M., Dowling, P., Crown, J., and O’Donovan, N

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Global gene repression by the steroid receptor coactivator SRC-1 promotes oncogenesis.

Cancer Research, March 2014

Walsh C, Bolger J, Byrne C, Cocchiglia S, Hao Y, Fagan A, Qin Li, Cahalin A, McCartan D, McIlroy M, Ó Gaora P, Xu J, Hill AD, Young LS

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miR-630 targets IGF1R to regulate response to HER-targeting drugs and overall cancer cell progression in HER2 over-expressing breast cancer.

Molecular Cancer, March 2014

Corcoran C, Rani S, Breslin S, Gogarty M, Ghobrial IM, Crown J, O’Driscoll L

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Growth factor receptor/steroid receptor cross talk in trastuzumab-treated breast cancer.

Oncogene, January 2014

Collins DC, Cocchiglia S, Tibbitts P, Solon G, Bane FT, McBryan J, Treumann A, Eustace A, Hennessy B, Hill AD, Young LS

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ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis

EMBO Molecular Medicine, December 2013

Romagnoli M, Mineva ND, Polmear M, Conrad C, Srinivasan S, Loussouarn D, Barillé-Nion S, Georgakoudi I, Dagg A, McDermott EW, Duffy MJ, McGowan PM, Schlomann U, Parsons M, Bartsch JW, Sonenshein GE

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Investigation of molecular alteration of AKT-3 in triple negative breast cancer.

Histopathology, December 2013

O’Hurley G, Daly E, O’Grady A, Cummins R, Quinn C, Flanagan L, Pierce A, Fan Y, Lynn MA, Rafferty M, Fitzgerald D, Pontén F, Duffy MJ, Jirström K, Kay EW, Gallagher WM

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Correlating transcriptional networks to breast cancer survival: a large scale coexpression analysis.

Carcinogenesis, October 2013

Clarke C, Madden SF, Doolan P, Aherne ST, Joyce H, O’Driscoll L, Gallagher WM, Hennessy BT

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Neratinib overcomes trastuzumab resistance in HER2 amplified breast cancer.

Oncotargets, October 2013

Canonici A, Gijsen M, Mullooly M, Bennett R, Bouguern N, Pedersen K, O’Brien NA, Roxanis I, Li JL, Bridge E, Finn R, Siamon D, McGowan P, Duffy MJ, O’Donovan N, Crown J, Kong A.

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